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Secondary bile salts / Secondary bile acids (SBAs)
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Contents
Nearly all of the bile acid pool in the large intestine comprises secondary bile acids, with concentrations reaching up to 1,000 µM. These secondary bile acids enter the enterohepatic circulation, are conjugated with glycine or taurine, and are re-released into the intestine. Any remaining bile acids are excreted through the feces
Tang et al. 2019a Nat Rev Cardiol. 16(3): 137-154
The Secondary bile salts / Secondary bile acids (SBAs) become enriched in the enterohepatic and [systemic circulation](brain://i9-iM1oIpEOeGPIjY5Oqkg/System…
References (Sources)
- Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease
- Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction
- Cancer and the microbiota
- Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice
- Manipulation of epithelial integrity and mucosal immunity by host and microbiota-derived metabolites
- Microbiome control of innate reactivityReview
- Overview of Bile Acids Signaling and Perspective on the Signal of Ursodeoxycholic Acid, the Most Hydrophilic Bile Acid, in the Heart