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Blood brain barrier (BBB) & Short-chain fatty acids (SCFAs)

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It was found that increased levels of circulating Short-Chain Fatty Acids (SCFAs) produced by the gut microbiome led to increased production of tight junction proteins, causing increased BBB integrity, and preventing entry of unwanted metabolites into brain tissue
Mohajeri et al. 2018a Nutr Rev. 76(7): 481-496

SCFAs secreted into the circulation could reach the brain and decrease the blood-brain barrier’s per…