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PROT3EcT secrete functional single-domain antibodies, and nanobodies (Nbs) and stably colonize and maintain an active secretion system within the intestines of mice
Furthermore, a single prophylactic dose of a variant of PROT3EcT that secretes a Tumor Necrosis Factor alfa (TNF-alfa)-neutralizing Nb is sufficient to ablate pro-inflammatory Tumor Necrosis Factor alfa (TNF-alfa) levels and prevent the development of injury and inflammation in a chemically induced model of colitis
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