CD4+ Th2 Cells & Cytokines

CD4+ Th2 cells are known to produce several important cytokines:

(1) Interleukin-4 (IL-4):
This is a signature cytokine of CD4+ Th2 Cells. Interleukin-4 (IL-4) is crucial for promoting B cell class switching to Immunoglobulin E (IgE) production, enhancing Th2 cell differentiation, suppressing CD4+ Th1 Cells development
Tymoshok et al. 2014 EPMA J. 5(Suppl 1): A134

(2) Interleukin-5 (IL-5):
This cytokine is primarily associated with eosinophil differentiation, activation, and survival
promoting B cell growth and antibody production
Mattes & Foster 2003 Curr Drug Targets Inflamm Allergy. 2(2): 169-74

(3) Interleukin-13 (IL-13):
Similar to Interleukin-4 (IL-4), Interleukin-13 (IL-13) is involved in IgE production, mucus hypersecretion, airway hyperresponsiveness in allergic conditions
Mattes & Foster 2003 Curr Drug Targets Inflamm Allergy. 2(2): 169-74

(4) Interleukin-10 (IL-10):
While not exclusively produced by CD4+ Th2 cells, it can be secreted by them and has immunoregulatory functions
Okahashi et al. 1996 Infect Immun. 64(5): 1516-25
Barrat et al. 2002 J Exp Med. 195(5): 603-16

see also:
CD4+ Th2 cells