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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Anti-inﬂammatory Activity / Anti-inflammatory Responses & Short-chain fatty acids (SCFAs)

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Anti-inﬂammatory activity by short-chain fatty acids (SCFAs) in DCs
--: created by meRfi-GmbH

This effect is dependent on the Na+ coupled monocarboxylate transporter Slc5a8, which transports butyrate and propionate into cells, and on the ability of these two bacterial metabolites to inhibit histone deacetylases.

--: ![Anti-inﬂammatory Activity by Short-chain fatty acids (SCFAs) in …

References (Sources)

Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation
Le Poul et al. 2003
Lactate transport in heart in relation to myocardial ischemia.
Halestrap et al. 1997 Am J Cardiol. 80(3A): 17A–25A
Manipulation of epithelial integrity and mucosal immunity by host and microbiota-derived metabolites
Kayama & Takeda 2020
The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens
Kim et al. 2017 Immunol Rev. 279(1): 90-105
The microbial metabolites, short chain fatty acids, regulate colonic Treg cell homeostasis
Smith et al. 2013
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
den Besten et al. 2013
Review
Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system
Postler & Ghosh 2017
Review

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Anti-inﬂammatory Activity / Anti-inflammatory Responses & Short-chain fatty acids (SCFAs)

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