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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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THP-1 cell line

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THP-1 cells could be successfully polarized into either the M1 or M2 state.
Chanput et al. 2013 Food Funct. 4: 266

The M1 phenotype is characterised by a high production of pro-inflammatory cytokines, such as TNFa, IL-1b, IL-6, IL-8 and IL-12, and by expression of pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs)
Gordon 2003 Nat. Rev. Immunol. 3: 23-35
Martinez et al. 2009 Annu. Rev. Immunol. 27: 451-483

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References (Sources)

Alternative activation of macrophages
Gordon 2003 Nat. Rev. Immunol. 3: 23-35
Alternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez et al. 2009 Annu. Rev. Immunol. 27: 451-483
Review
Characterization of polarized THP-1 macrophages and polarizing ability of LPS and food compounds
Chanput et al. 2013 Food Funct. 4: 266

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THP-1 cell line

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