Escherichia coli Nissle 1917 / E. coli Nissle 1917 (EcN)

Escherichia coli strain Nissle 1917 (EcN) is known to reduce Food Intake / Eating and increase Energy expenditure
Park et al. 2021a Nutrients 13: 811

It is relatively safe for therapeutic applications because it does not cause colitis
Gronbach et al. 2010 Infect. Immun. 78: 3036
Yu et al. 2019a JCI Insight. 4(16): e125166

The strain Escherichia coli Nissle 1917 / E. coli Nissle 1917 (EcN) is a non-pathogenic fecal bacterium, well studied as probiotic and exerts probiotic effects in humans and animals
Kruis et al. 1997 Aliment. Pharmacol. Ther. 11: 853-858
D’Souza et al. 2002 BMJ 324: 1361
Duncker et al. 2006 Vet. Immunol. Immunopathol. 111: 239-250
Kim et al. 2017 Immunol Rev. 279(1): 90-105

It produces two microcins
Kim et al. 2017 Immunol Rev. 279(1): 90-105

Nissle 1917 may further promote immune regulation by promoting the expansion of plasmacytoid DC, Foxp3 − Ror gamma/t + CD4 + T cells and Foxp3 + Rorγt + Helios − CD4 T cells in the Colon / Large Intestine and contraction of CD11b + CD11c − F4/80 + monocytes in the small intestine as compared to germfree mice
Geva-Zatorsky et al. 2017 Cell 168: 928-943

Studies have revealed that Escherichia coli Nissle 1917 / E. coli Nissle 1917 (EcN) produces three main kinds of adhesins: F17-like pili, type 1 pili, and F1C pili
Lasaro et al. 2009 Appl Environ Microbiol. 75: 246-51
O’Connell Motherway et al. 2011 Proc Natl Acad Sci USA. 108: 11217–22

This strain was initially isolated from the gut of a German soldier who, unlike his comrades, displayed resistance to endemic shigellosis during World War I
Hancock et al. 2010 J. Med. Microbiol. 59: 392-399

Escherichia coli strain Nissle 1917 (EcN) does not produce any virulence factors, carry any genes for pathogenicity traits, or form enterotoxins, cytotoxins, or hemolysins
Blum et al. 1995 Infection 23: 234-236

see also:
intelligent, responsive bacteria for diagnosis and therapy (i-ROBOT)
Mutaflor TM