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Clostridium species, particularly Clostridium Cluster IV and Clostridium Cluster XIVa, have been shown to play a significant role in modulating immune responses, including those involving Immunoglobulin E (IgE). These bacteria are part of the indigenous intestinal microbiota and are known to promote the accumulation of regulatory T cells (Tregs) in the colon. Tregs are crucial for maintaining immune homeostasis and preventing excessive immune responses tha…