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The "LEAP" study highlighted the "window of tolerance." This is an optimal time for oral tolerance induction. It coincides with weaning. The shift from breastfeeding to solid food changes gut bacteria. This change is critical for immune development.
Additionally, early introduction of food allergens like peanuts and eggs has shown limited efficacy in inducing tolerance, highlighting the challenges of oral tolerance induction in early life
Scarpone et al. 2023 JAMA Pedia…