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Cisplatin & Gut microbiota
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Retrospective clinical analysis of patients with ovarian cancer indicates that antibiotic use during chemotherapy treatment is associated with poor overall survival.
Tumor-bearing antibiotic-treated mice exhibited accelerated tumor growth and resistance to cisplatin therapy compared with control treatment.
Antibiotic treatment led to reduced apoptosis, increased DNA damage repair, and enhanced angiogenesis in cisplatin-treated tumors.
Tumors from antibiotic-treated mice contained a higher frequency of cisplatin-augmented cancer stem cells than those from control mice.
Stool analysis indicated t…