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Evidence from animal and human microbiota studies demonstrates that microbial composition modulates CYP3A through gene expression regulation, metabolite interactions, and nuclear receptor pathways, leading to variability in drug metabolism and clearance.
Secondary bile acids (e.g., lithocholic acid) and indole derivatives may induce Cytochrome P450 3A (CYP3A) activity by interacting with host signaling pathways
Gut microbiota modulates cyp3a11 gene transcriptio…