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Lithocholic acid (LCA)
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Contents
Lithocholic acid (LCA) feeding resulted in severe liver damage and activation of the NLRP3 inflammasome
Kupffer cells (KC) were the most affected cells, resulting in a pro-inflammatory phenotype .
Lithocholic acid (LCA) is the main bile acid ligand for the pregnane X receptor, Vitamin D receptor (VDR) is activated by LCA, but not by other [Bile acids / Bile salts](brain://7ZdBK_faqEi6LCdQO4CGnQ/BileAcidsBi…
References (Sources)
- Alterations in Bile Acid Metabolism Associated With Inflammatory Bowel Disease
- Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation
- Functional food science and gastrointestinal physiology and functionReview
- Interactions between bile salts, gut microbiota, and hepatic innate immunity
- Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the vitamin D receptor
- Manipulation of epithelial integrity and mucosal immunity by host and microbiota-derived metabolites
- Overview of Bile Acids Signaling and Perspective on the Signal of Ursodeoxycholic Acid, the Most Hydrophilic Bile Acid, in the Heart