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Kupffer cells
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Contents
Eradication of pathogens from the bloodstream is critical to prevent disseminated infections and sepsis. Kupffer cells in the liver form an intravascular firewall that captures and clears pathogens from the blood. The catching and killing of circulating pathogens by Kupffer cells in vivo are promoted by the gut microbiota. This process is facilitated through commensal-derived D-lactate that reaches the liver via the portal vein.
McDonald et al. 2020 Cell Host &…