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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Gut microbiota & Indole / Indoles

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Indole and its derivatives are major bacterial metabolites produced from diet tryptophan
Chen & Chen 2021 Cancers 13: 4054

Indole is absorbed by host cells and strengthens the integrity of the intestinal barrier, being regarded as a beneﬁcial chemical cue within microbial and/or host interactions
Bansal et al. 2010 Proc. Natl. Acad. Sci. USA 107: 228-233

indole decreases expression of virulence genes in EHEC
Kumar & Sperandio 2019 mBio 10:…

References (Sources)

Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells
Chimerel et al. 2014 Cell Rep 9(4): 1202-1208
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD
Wong et al. 2014 Am J Nephrol. 39: 230-237
Indole as an intercellular signal in microbial communities
Lee & Lee 2010 FEMS Microbiol. Rev. 34: 426-444
Review
Indole signaling at the host-microbiotapathogen interface
Kumar & Sperandio 2019 mBio 10: e01031-19
Indole-3-lactic acid as a tryptophan metabolite produced by Bifidobacterium spp
Aragozzini et al. 1979 Appl. Environ. Microbiol. 38: 544-546
Indoles from commensal bacteria extend healthspan
Sonowal et al. 2017 Proc Natl Acad Sci USA 114: E7506-E7515
Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions
Zhang & Davies 2016 Genome Med. 8(1): 46
Review

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Gut microbiota & Indole / Indoles

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