Self antigens / Autoantigens / Autoimmunity

Self-antigens generally have poor antigenicity.

Checkpoint Pathways should prevent autoimmunity. Self-antigens, also called autoantigens, are normal proteins or protein complexes recognized by the immune system of people with autoimmune diseases. These autoantigens can include peptides, DNA, or RNA.

Examples of autoantigens include:

• Myelin antigens in multiple sclerosis.

References:
Smith & Allen 1991 Curr Opin Immunol. 3(1): 22-5
Patel & Minn 2018 Immunity 48: 417
Pauken et al. 2019

see also:
Autoimmune Diseases
Colitis / Intestinal Inflammation & Interleukin-10 (IL-10)
Interleukin-10 (IL-10)