meRfi®-GM
Colitis / Intestinal Inflammation & Interleukin-10 (IL-10)
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Contents
Previous studies show that Toll-Like Receptors (TLRs) signals change macrophage lipids (Macrophages (CD68s) & Toll-like receptor 2 (TLR-2)). This affects their function. Interleukin-10 (IL-10) is made after some Toll-Like Receptors (TLRs) are activated. It helps resolve inflammation. Interleukin-10 (IL-10) signalling led to more ceramides and modified ceramides. There was also a decrease in sphingomyelins.
Interleukin-10 (IL-10) signalling regulates [sphingolipid](brain://aIirqs…
References (Sources)
- IL-10 modulates DSS-induced colitis through a macrophage–ROS–NO axis
- Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins
- Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2
- Metabolic reprogramming in macrophages and dendritic cells in innate immunity
- Multi-“-Omics” Profiling in Patients With Quiescent Inflammatory Bowel Disease Identifies Biomarkers Predicting Relapse
- The complex role of interleukin-10 in autoimmunity
- Toll-like receptors induce signal-specific reprogramming of the macrophage lipidome