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Several studies have shown that inflammation can affect the sphingolipid salvage pathways. However, less is known about how inflammatory signals influence the regulation of de novo sphingolipid synthesis. Neutral sphingomyelinase 2 plays a role in controlling the inflammatory responses in monocytes and macrophages that are triggered by Tumor Necrosis Factor alfa (TNF-alfa). The inhibition of Acid sphingomyelinase reduces the release of inflammatory cytokines from ma…