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In 1989, the hygiene hypothesis was originated. According to this hypothesis, Homo sapiens evolved and co-lived with friendly microorganisms in their bodies for thousands of years. The hygiene hypothesis suggests urbanization reduces exposure to these microorganisms. Less exposure can hinder immune development. It has contributed to the rising rates of allergic diseases, including asthma and may cause diseases like multiple sclerosis, lupus, and [allergies](brain://UB6bJu0unUq8OIkp2gHycA/AllergicReactionsAllergiesGutMicrobiot…