meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond
Hygiene Hypothesis
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Contents
In 1989, the hygiene hypothesis was originated. According to this hypothesis, Homo sapiens evolved and co-lived with friendly microorganisms in their bodies for thousands of years. The hygiene hypothesis suggests urbanization reduces exposure to these microorganisms. Less exposure can hinder immune development. This may cause diseases like multiple sclerosis, lupus, and allergies
Microorganisms are vital for immune system development
Fan & Pedersen 202…
References (Sources)
- 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Darwinian medicine and the ‘hygiene’ or ‘old friends’ hypothesis
- Gut microbiota in human metabolic health and disease
- Hay Fever, Hygiene, and Household Size
- Hygiene and other early childhood influences on the subsequent function of the immune system
- Hygiene hypothesis in inflammatory bowel disease: a critical review of the literature
- Innate immune responses to mycobacteria and the downregulation of atopic responses
- The immunology of the allergy epidemic and the hygiene hypothesis