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Gut dysbiosis caused a reduction in Insulin-like growth factor 1 (IGF-1) expression in mLN tissue and induced hyperreactivity of RA signaling and IFN-I response in mLN.
The IGF-1/Akt pathway inhibits RA signaling and the IFN-I response, which positively affects CD4+ Th2 cells differentiation.
In ov…