Loading…

Medical Research Finder

Legal Notice
Privacy
Terms of Use

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

meRfi® AI Chat

Farnesoid X receptor (FXR / NR1H4) agonists

Welcome to meRfi-GM!

Please register to continue your trial period!

meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.

Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.

Start your free trial and transform your understanding of the gut microbiota today!

(Login)

Navigation

Key features:
Agonists activate Farnesoid X Receptor (FXR / NR1H4)

In enterocytes conjugated bile acids activate FXR
Fuchs & Trauner 2022 Nat Rev Gastroenterol Hepatol 19: 432-450

Activation of Farnesoid X receptor (FXR / NR1H4) favors the expression of Occludin, Claudin 1, and ZO1, maintaining [epithelial barrier integrity](brain://x8ztgCp9RU6lQnz1P-5Q8g/EpithelialBarrierIntegrityMuco…

References (Sources)

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)
Tully et al. 2017 J Med Chem. 60(24): 9960-9973
Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
Gadaleta et al. 2011 Gut 60: 463-472
Farnesoid X Receptor Agonists: A Promising Therapeutic Strategy for Gastrointestinal Diseases
Almeqdadi & Gordon 2023 Gastro Hep Adv 3(3): 344-352
Review
Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response
Wang et al. 2008 Hepatology 48: 1632-43
FXR and TGR5 Agonists Ameliorate Liver Injury, Steatosis, and Inﬂammation After Binge or Prolonged Alcohol Feeding in Mice
Iracheta-Vellve et al. 2018 Hepatol. Commun. 2: 1379-1391
Key Signaling in Alcohol-Associated Liver Disease: The Role of Bile Acids
Way et al. 2022 Cells 11: 1374
Review
Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology
Fuchs & Trauner 2022 Nat Rev Gastroenterol Hepatol 19: 432-450
Review

AI Chat

5/29/2026

Chat with our artificial intelligence:

Start chat!

Farnesoid X receptor (FXR / NR1H4) agonists

Welcome to meRfi-GM!

Navigation

Contents

References (Sources)

AI Chat