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CTLA-4 and Programmed cell death protein 1 (PD-1 )/ Programmed death-ligand 1 (PD-L1) molecules are the most studied inhibitory immune checkpoints against cancer and because of this therapeutic property have entered the clinic for treating a variety of tumor types.
Checkpoint molecules are now sufficiently numerous such that they can be divided into families
Janakiram et al. 2017
see also:
B7-CD28 immune checkpoint family…