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Collectively, indole metabolites (Indoles) have protective effects on the development of Colorectal Tumorigenesis in an AhR-dependent manner, including inhibiting inflammation, promoting barrier function, and restraining the hyperproliferation of intestinal stem cells
Indoles promote epithelial barrier function, e.g. by supporting the maintenance of Group 3 ILCs (ILC3), which are der primary producers of IL-22
see also:
Group 3 ILCs (ILC3) & Interleukin-22 (IL-22)
Indole / Indoles