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Collectively, indole metabolites (Indoles) have protective effects on the development of Colorectal Tumorigenesis in an AhR-dependent manner, including inhibiting inflammation, promoting barrier function, and restraining the hyperproliferation of intestinal stem cells
Indoles promote epithelial barrier function, e.g. by supporting the maintenance of [Group 3 ILCs (ILC3)](brain://S0n9R2RF1k6d42B-x9oXyg/Group3I…