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The Aryl Hydrocarbon Receptor (AhR) is a ligand-activated transcription factor that plays a crucial role in modulating intestinal immune responses (1). AhR induces its negative regulator, the AHR repressor (AHRR), which is vital for sustaining intestinal intraepithelial lymphocytes (IELs) (1).
References:
(1)
The aryl hydrocarbon receptor acts as a mediator in the interaction between the host and microbiota.
Situated in the cytoplasm in an inactive complex, Aryl Hydrocarbon Receptor (AhR) translocates into the nucleus upon ligand bin…