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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Activation / Activators & Aryl Hydrocarbon Receptor (AhR)

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Aryl Hydrocarbon Receptor (AhR) activation increases the Biosynthesis of Polyamines
Proietti et al. 2020 Trends in immunology 41: 1037

In an experimental colitis model in mice, indole-3-pyruvic acid (IPyA), Tryptophol, and indole-3-aldehyde (IAld) improve intestinal barrier integrity by activating Aryl Hydrocarbon Receptor (AhR)
Scott et al. 2020a Proc Natl Acad Sci USA 117: 19376-19387

see also:
Aryl Hydrocarbon Receptor (AhR) & Indole / Indoles
Tryptophan metabolites

References (Sources)

Detrimental activation of AhR pathway in cancer: an overview of therapeutic strategies
Leclerc et al. 2021a Current Opinion Immunology 70: 15-26
Review
Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation
Li et al. 2011 Cell 147: 629–640
External inﬂuences on the immune system via activation of the aryl hydrocarbon receptor
Stockinger et al. 2011 Semin. Immunol. 23: 99-105
Review
Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor
Scott et al. 2020a Proc Natl Acad Sci USA 117: 19376-19387
Polyamines and Kynurenines at the Intersection of Immune Modulation
Proietti et al. 2020 Trends in immunology 41: 1037
Review

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5/29/2026

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