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The IDO-dependent kynurenine (Kyn) pathway of tryptophan metabolism is a significant source of endogenous Aryl Hydrocarbon Receptor (AhR) agonists. Through this metabolic pathway, the AhR has the ability to enhance the expression of Indoleamine 2,3-Dioxygenase (IDO) / Indoleamine 2,3-dioxygenase 2 (IDO2), which in turn produces AhR ligands such as Kyn.
AhR agonists activate the receptor. This leads to its …