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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Probiotics (living agents) & Anxiety / Anxiety Disorder

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Although direct oral consumption of 4-Aminobutyric acid / GABA can treat Anxiety / Anxiety Disorder (Hepsomali et al. 2020 Frontiers in Neuroscience 14: 923), probiotics containing strains that naturally produce GABA within the human gut are not currently used in anxiety treatment.
Grant et al. 2025 Benef Microbes Apr 24: 1-12 doi: 10.1163/18762891-bja00073

There is no signiﬁcant correlation between probiotics and anxiety and depression levels in cancer patients. …

References (Sources)

A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome
Rao et al. 2009 Gut Pathog. 1(1): 6
Lactiplantibacillus plantarum Lp815 decreases anxiety in people with mild to moderate anxiety: a direct-to-consumer, randomised, double-blind, placebo-controlled study
Grant et al. 2025 Benef Microbes Apr 24: 1-12 doi: 10.1163/18762891-bja00073
Probiotic Escherichia coli Ameliorates Antibiotic-Associated Anxiety Responses in Mice
Park et al. 2021a Nutrients 13: 811
Probiotic Lactobacillus casei strain Shirota relieves stress-associated symptoms by modulating the gut-brain interaction in human and animal models
Takada et al. 2016 Neurogastroenterol. Motil. 28(7): 1027-1036
Probiotics as a treatment for prenatal maternal anxiety and depression: A double-blind randomized pilot trial
Browne et al. 2021a Sci. Rep. 211: 3051
Protective Effects of Probiotics on Cognitive and Motor Functions, Anxiety Level, Visceral Sensitivity, Oxidative Stress and Microbiota in Mice with Antibiotic-Induced Dysbiosis
Arslanova et al. 2021 Life 11: 764
The effects of probiotics on mental health and hypothalamic-pituitary-adrenal axis: A randomized, double-blind, placebo-controlled trial in petrochemical workers
Mohammadi et al. 2016 Nutr. Neurosci. 19(9): 387-395

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12/17/2025

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