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The disturbed integrity of the intestinal epithelial barrier seems to trigger chronic inflammatory processes.
In this context, ILCs are important as they are located close to the mucosa . They are in constant bi-directional exchange with IECs .
The destruction of gut barrier may promote the development of IBD, T1D, and NAFLD
The defective colonic NLRP6 inflammasome is responsible for intestinal epithelial barrier impairment.
If epithelial barrier defences are breached by microorganisms or their products, immune and mesenchymal cells act as a second line of defence by initiating a cascade of signaling networks that uphold epithelial integrity
Transepithelial migration is specifically associated with diminished barrier function, and while neutrophils in the lumen may kill pathogenic microbes, their sustained activity can cause intestinal damage
Infectious, Toxic and Allergenic Material from the Internal Milieu Must Be Warded Off