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Previous studies show that Toll-Like Receptors (TLRs) signals change macrophage lipids (Macrophages (CD68s) & Toll-like receptor 2 (TLR-2)). This affects their function. Interleukin-10 (IL-10) is made after some Toll-Like Receptors (TLRs) are activated. It helps resolve inflammation. Interleukin-10 (IL-10) signalling led to more ceramides and modified ceramides. There was also a decrease in sphingomyelins.
Interleukin-10 (IL-10) signalling regulates [sphingolipid](brain://aIirqs…