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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Biosynthesis & Cholesterol

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Contents

Cholesterol biosynthesis is a complex, 37-step process that occurs in all animal cells, primarily in the liver. It is an essential structural component of animal cell membranes.

This begins with the mevalonate or HMG-CoA reductase (HMGCR) (pathway) pathway, which encompasses the first 18 steps. HMG-CoA reductase (HMGCR) (pathway) initially biosynthesizes mevalonate from acetyl-CoA.
Geisslinger et al. 2020 Wissenschaftliche Verlagsgesellschaft mbH ISBN 978-3-8047-3663-4

This is followed by 19 additional steps to convert the resulting lanosterol into chol…

References (Sources)

A comprehensive analysis of the microbiota composition and gene expression in colorectal cancer
Zhang et al. 2020w BMC Microbiology 20: 308
Biosynthesis of cholesterol and other sterols
Nes 2011 Chem Rev. 111(10): 6423-51
Review
Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol ∆24-reductase
Bae & Paik 1997 Biochem. J. 326: 609-616
Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein
Bae et al. 1999 Journal of Biological Chemistry 274(21): 14624-14631
Formation of sterols in animals
Gaylor 1981 in Biochemistry of Isoprenoids (Porter, J. W., and Springer, S. L., eds) 1: 482–543, John Wiley & Sons, Inc., New York
Limiting cholesterol biosynthetic flux spontaneously engages type I IFN signaling
York et al. 2015 Cell 163: 1716-1729
Mutschler Arzneimittelwirkungen
Geisslinger et al. 2020 Wissenschaftliche Verlagsgesellschaft mbH ISBN 978-3-8047-3663-4

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