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Biosynthesis & Cholesterol
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Contents
Cholesterol biosynthesis is a complex, 37-step process that occurs in all animal cells, primarily in the liver. It is an essential structural component of animal cell membranes.
This begins with the mevalonate or HMG-CoA reductase (HMGCR) (pathway) pathway, which encompasses the first 18 steps. HMG-CoA reductase (HMGCR) (pathway) initially biosynthesizes mevalonate from acetyl-CoA.
This is followed by 19 additional steps to convert the resulting lanosterol into chol…
References (Sources)
- A comprehensive analysis of the microbiota composition and gene expression in colorectal cancer
- Biosynthesis of cholesterol and other sterols
- Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol ∆24-reductase
- Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein
- Formation of sterols in animals
- Limiting cholesterol biosynthetic flux spontaneously engages type I IFN signaling
- Mutschler Arzneimittelwirkungen