Intestine GVHD

Broad-spectrum antibiotics (ATB) such as carbapenems increase the risk of intestinal GVHD
Hayase et al. 2022 Cell 185(20): 3705-3719

The carbapenem meropenem exacerbates colonic GvHD in mice via expansion of Bacteroides thetaiotaomicron (BT)
Hayase et al. 2022 Cell 185(20): 3705-3719

Patients with Intestine GVHD refractory to treatment with glucocorticosteroids, considered the first-line therapy, have a dismal prognosis with survival rates as low as 5%
Westin et al. 2011 Adv Hematol 2011: 601953
Castilla-Llorente et al. 2014 Bone Marrow Transplant 49(7): 966-71

Currently, there is no standard for second-line therapy for Intestine GVHD
Martin et al. 2012 Biol Blood Marrow Transplant 18(8): 1150-63

Interestingly, the gastrointestinal (GI) tract plays a vital role in the cytokine release site and the whole process of acute graft-versus-host disease (GVHD ) initiation
Hanash et al. 2012 Immunity 37: 339–350

Cells that are known to be particularly damaged during the conditioning therapy are Paneth and goblet cells .
Bilinski et al. 2022 Biomedicines 10: 837