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Small intestinal Paneth cells, residing at the crypt base, have a lifespan of about 3–6 weeks.
Paneth cells secrete a variety of antibacterial substances, such as antimicrobial peptides and Regenerating Islet-Derived Protein 3 Gamma / Regenerating Islet-Derived Protein III-Gamma (REG3G). The antibacterial substances and secretory IgA are secreted into mucus to protect against commensal pathogens
Paneth cells are intestinal epithelial cells that play a role in the intestinal epithelial barrier.
Loss of these cells results in intestinal dysbiosis
Paneth cells are intestinal epithelial cells (IECs) distinguished by their secretory antimicrobial granules and position within the Small intestinal crypts adjacent to LGR5+ Epithelial stem cells
Paneth cells are responsible for secreting antimicrobial peptides and proteins.
Paneth cells produce cytokines essential for the maintenance of the Intestinal Stem Cells (ISCs) niche.
Paneth cells have been suggested to regulate microbiota-induced intestinal angiogenesis in mice, but they also have a large effect on angiogenesis independently of colonization status