Loading…

Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Paneth Cells

Welcome to meRfi-GM!

Please register to continue your trial period!

meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.

Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.

Start your free trial and transform your understanding of the gut microbiota today!

Small intestinal Paneth cells, residing at the crypt base, have a lifespan of about 3–6 weeks.
Kayisoglu et al. 2021

Paneth cells secrete a variety of antibacterial substances, such as antimicrobial peptides and Regenerating Islet-Derived Protein 3 Gamma / Regenerating Islet-Derived Protein III-Gamma (REG3G). The antibacterial substances and secretory IgA are secreted into mucus to protect against commensal pathogens
Liu et al…

Decreased secretion of Paneth cell α-defensins in graft-versus-host disease
Eriguchi et al. 2015 Transpl. Infect. Dis. 17: 702-706
Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
Stappenbeck et al. 2002
Paneth cells: maestros of the small intestinal crypts
Clevers et al. 2013 Annu. Rev. Physiol. 75: 289-311
Review
Signaling pathways in intestinal development and cancer
Sancho et al. 2004 Annu Rev Cell Dev Biol 20: 695-723
Review
Surface components and metabolites of probiotics for regulation of intestinal epithelial barrier
Liu et al. 2020a
Review
The intestinal epithelium tuft cells: specification and function
Gerbe et al. 2012 Cell Mol Life Sci. 69: 2907-2917
Review
γδ IEL effector API5 masks genetic susceptibility to Paneth cell death
Matsuzawa-Ishimoto et al. 2020 Nature 610: 547–554

12/16/2025