meRfi®-GM
Tight-Junction Molecules / Tight Junction Proteins
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Contents
Key features:
= a ring of proteins that seals apical epithelium; includes the integral membrane proteins occludin and claudin, in association with cytoplasmic Zonula Occludens (ZO) Proteins (Zoludins)
Occludin plays a role in regulating interactions between occludin and Zonula Occludens Protein-1 (ZO-1), which helps maintain a complete tight junction (TJ) complex and supports paracellular barrier function. Studies indicate that [short-chain fa…
References (Sources)
- Ca2+ regulation of tight-junction permeability and structure in Necturus gallbladder
- Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease
- Functions of Claudin Tight Junction Proteins and Their Complex Interactions in Various Physiological Systems
- Interferon-gamma directly affects barrier function of cultured human epithelial monolayers
- Negative Effects of a High-Fat Diet on Intestinal Permeability: A ReviewReview
- The FXR agonist obeticholic acid prevents gut barrier dysfunction and bacterial translocation in cholestatic rats
- Tight Junctions and the Intestinal Barrier