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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

Paneth Cells

Small intestinal Paneth cells, residing at the crypt base, have a lifespan of about 3–6 weeks.
Kayisoglu et al. 2021

Paneth cells secrete a variety of antibacterial substances, such as antimicrobial peptides and Regenerating Islet-Derived Protein 3 Gamma / Regenerating Islet-Derived Protein III-Gamma (REG3G). The antibacterial substances and secretory IgA are secreted into mucus to protect against commensal pathogens
Liu et al…

Decreased secretion of Paneth cell α-defensins in graft-versus-host disease
Eriguchi et al. 2015 Transpl. Infect. Dis. 17: 702-706
Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
Stappenbeck et al. 2002
Paneth cells: maestros of the small intestinal crypts
Clevers et al. 2013 Annu. Rev. Physiol. 75: 289-311
Review
Signaling pathways in intestinal development and cancer
Sancho et al. 2004 Annu Rev Cell Dev Biol 20: 695-723
Review
Surface components and metabolites of probiotics for regulation of intestinal epithelial barrier
Liu et al. 2020a
Review
The intestinal epithelium tuft cells: specification and function
Gerbe et al. 2012 Cell Mol Life Sci. 69: 2907-2917
Review
γδ IEL effector API5 masks genetic susceptibility to Paneth cell death
Matsuzawa-Ishimoto et al. 2020 Nature 610: 547–554

4/13/2026

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