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Cefprozil decreased activity of multiple Cytochrome P450 Superfamily isoforms including CYP1A2, CYP2C19, and CYP3A4. CYP2C19 is the most important CYP for metabolizing Omeprazole. That means, omeprazol metabolites decreased.
see also:
Cytochrome P450 3A (CYP3A) & Gut microbiota
[Drugs / Medications & Gut microbiota](brain://ZBGW_qogUk-yMxtDB0eAng/DrugsMedicationsGutMicrobio…