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Iron metabolism is controlled systemically by hepcidin, which induces the degradation of the iron exporter ferroportin and thereby limits extracellular efflux of iron
Iron availability is regulated by the liver-derived hormone hepcidin. Increased hepcidin production occurs in response to infection and inflammation and leads to reduced iron availability, a mechanism of host protection
Hepcidin is a key regulator of the entry of iron into the circulation in mammals
Ganz 2003 Blood. 102 (3): 783–8
Abnormally high levels of hepcidin typically leads to anemia due to an inadequate amount of serum iron being available…