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Hepcidin
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Contents
Iron metabolism is controlled systemically by hepcidin, which induces the degradation of the iron exporter ferroportin and thereby limits extracellular efflux of iron
Iron availability is regulated by the liver-derived hormone hepcidin. Increased hepcidin production occurs in response to infection and inflammation and leads to reduced iron availability, a mechanism of host protection
Hepcidin is a key regulator of the entry of iron into the circulation in mammals
Ganz 2003 Blood. 102 (3): 783–8
Abnormally high levels of hepcidin typically leads to anemia due to an inadequate amount of serum iron being available…
References (Sources)
- Current understanding of iron homeostasis
- Dendritic cell–derived hepcidin sequesters iron from the microbiota to promote mucosal healing
- Hepcidin as a therapeutic target for anemia and inflammation associated with chronic kidney disease
- Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
- Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
- IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
- Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms