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Propionate is involved in gluconeogenesis in the liver, promotion of satiety, and cholesterol reduction
Increased concentrations of propionate in the portal vein would be taken up by the liver and stimulate hepatic gluconeogenesis. An increased hepatic energy status can modulate feeding behaviour via the stimulation of hepatic vagal nerve afferents
see also:
Biological effects / Functions & Propanoate Metabolism / Propionate / Propionic acid