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Bte1
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Bte1 is a Type VI Secretion System (T6SS)-dependent (contact-dependent) effector, widely found in human gut microbiome genomes and metagenomes, particularly in bacteria like Bacteroides.
Ross et al. 2019b Nature 575: 224–228
Bte1 has no discernible motives. Domains are missing. Homologs are also absent. This makes structure predictions difficult. The metagenomic signature is clear. It shows Bte1 as an important component. It acts in the human gut microbiome. However, the cellular targets are unknown. The mechanism of action is also unclear.
Bte1 disrupts the ability of the periplasmic PpiD-YfgM chaperone complex in neighboring microbes for protein foldin…