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In the quest to discover the most effective cancer therapy, it is important to take into account not only the somatic mutations present in cancer cells but also the germline gene variations that play a role in regulating immune responses .
A comprehensive evaluation was conducted on 187 studies concerning cancer treatment, which resulted in 176 approvals for 75 distinct novel cancer drugs by the FDA. Among these studies, 64 (34%) were single-arm clinical trials, while 123 (63%) were randomized clinical trials. Within the 123 randomized clinical trials, 37 (30%) demonstrated no survival benefit, 31 (25%) exhibited suboptimal control, and 17 (14%) involved ina…