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Alarmins / Damage-associated molecular pattern (DAMPs)
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Contents
Interleukin-33 (IL-33 ) acts as an alarmin cytokine by alerting the system of potential environmental stresses
Dangerous entities, such as PAMPs or alarmins are produced under conditions of stress (as occurs with tissue damage or in infections )
Damage Associated Molecular Pattern Molecules (DAMPs) are released from cancer cells due to necrotic death .
The endogenous molecules from stressed or damaged cells are called DAMPs
Patel & Minn 2018 Immun…
References (Sources)
- Does T Cell Activation Require a Quorum of Lymphocytes?
- Dying cells actively regulate adaptive immune responsesReview
- Emerging inflammasome effector mechanismReview
- Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C
- Innate and adaptive effects of inflammasomes on T cell response
- Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis
- Sterile inflammation: sensing and reacting to damage.