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Gasdermin proteins form large membrane pores in human cells that release immune cytokines and induce lytic cell death.
Gasdermin pore formation is triggered by caspase-mediated cleavage during inflammasome signaling.
In bacteria, encoded gasdermin homologs defend themselves against phages and induce cell death.
Cleavage of gasdermin D (GSDMD) by caspase-8 (CASP8) leads to pyroptosis.
see also:
[Cell Death & Inflammation / Inflammatory Diseases](brain://kLADX5rhpkWHw9ApphFRZA/CellDeathInflammatio…