meRfi®-GM
Gasdermin D (GSDMD)
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Contents
IECs accumulate a lesser-known 13-kD N-terminal fragment of GSDMD. This is cleaved by caspase-3 and caspase-7 in response to food antigens
In contrast to the 30-kD GSDMD cleavage fragment that carries out pyroptosis, the IEC-accumulated 13-kD N-terminal fragment of GSDMD translocates into the nucleus. It induces transcription of CIITA and MHCII molecules, activating the Tr1 -Cells induced in the upper [smal…
References (Sources)
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion
- Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine
- GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
- Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
- NLRP3 and pyroptosis blockers for treating inflammatory diseases