meRfi®-GM
Caspases (cysteine-dependent aspartate-specific proteases) & Pyroptosis
Welcome to meRfi-GM!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Navigation
Contents
Pyroptosis can be triggered via the canonical caspase-1 pathway and caspase-4, caspase-5, and caspase-11-mediated pathways. These caspases can directly recognize cytosolic lipopolysaccharide (LPS) from Gram-negative bacteria, leading to the cleavage of gasdermin D (GSDMD) and the induction of pyroptosis. Cleavage of GSDMD by caspases leads to the formation of the pore-forming [GSDMD-N Domain](brai…