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Alzheimer's Disease (AD) & Tau Protein
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Contents
tautangles (NFT) are present within the neurons
In Alzheimer's Disease (AD), phosphorylated Akt undergoes sulfhydration at C77 due to elevated hydrogen sulfide (H₂S) levels linked to IL-1beta-mediated inflammation. The sulfhydration of AKT initiates the phosphorylation of Tau by activating Glycogen synthase kinase-3 beta (GSK-3 beta)
Sen et al. 2020 Proc Natl Acad Sci USA 117(8): 4418-…
References (Sources)
- Alzheimer’s disease: phenotypic approaches using disease models and the targeting of tau protein
- APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
- Focusing on oligomeric tau as a therapeutic target in Alzheimer’s disease and other tauopathies
- Probiotics for Alzheimer’s Disease: A Systematic Review
- Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3β in Alzheimer’s disease
- The Role of Glycogen Synthase Kinase-3 (GSK-3) in Alzheimer’s Disease