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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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ST2 receptor

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The Interleukin-33 (IL-33) receptor, known as ST2, is found on many immune cells. It is crucial for type 2 immune functions. ST2 is also present on CD4 and CD8 T cells during type 1 responses.
Schmitz et al. 2005 Immunity 23: 479-490
van der Ploeg et al. 2023 Nat Commun 14: 5137

When IL-33 binds, ST2 pairs with Interleukin-1 Receptor Accessory Protein (IL1RAcP). This activates NF-kB and Mitogen-activated protein kinases (MAPKs or MAP kinases) through the [M…

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IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
Schmitz et al. 2005 Immunity 23: 479-490
T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses
Baumann et al. 2015 Proc Natl Acad Sci USA 112: 4056-4061
Type-2 CD8+ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations
van der Ploeg et al. 2023 Nat Commun 14: 5137

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ST2 receptor

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