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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

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Candidatus Savagella (Segmented filamentous bacteria/SFB) & Targets

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CD11c + dendritic cells as target

SAA acts on CD11c + dendritic cells to trigger production of IL-1 beta and Interleukin-23 (IL-23) - the latter of which stimulates group 3 innate lymphoid cells to release IL-22 , which then synergizes with IL-1 beta to maximize Enterocytes / Intestinal Epithelial Cells (IECs) secretion of SAA.
Atarashi et al. 2015 Cell 163(2): 367–80

Enterocytes / Intestinal Epithelial Cells (IECs) as target

A critical feature of Candidatus Savagella (Seg…

References (Sources)

An IL-23R/IL-22 circuit regulates epithelial serum amyloid A to promote local eﬀector Th17 responses.
Sano et al. 2015 Cell 163: 381–393
TH17 cell and epithelial cell crosstalk during inﬂammatory bowel disease and carcinogenesis
Kempski et al. 2017
Review
Th17 cell induction by adhesion of microbes to intestinal epithelial cells
Atarashi et al. 2015 Cell 163(2): 367–80

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