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IECs accumulate a lesser-known 13-kD N-terminal fragment of GSDMD. This is cleaved by caspase-3 and caspase-7 in response to food antigens
In contrast to the 30-kD GSDMD cleavage fragment that carries out pyroptosis, the IEC-accumulated 13-kD N-terminal fragment of GSDMD translocates into the nucleus. It induces transcription of CIITA and MHCII molecules, activating the Tr1 -Cells induced in the upper [smal…