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The study explores the initiation of Alzheimer's disease (AD) through the seeded growth of pathogenic protein aggregates. It highlights the genetic link of sporadic Alzheimer's disease (AD) to apolipoprotein E (APOE) and genes in microglia associated with immune, lipid, and endocytic functions. Researchers developed a transgenic mouse model expressing HaloTag-tagged APOE to purify APOE biochemically. They discovered fibrillary aggregates of APOE in mice with amyloid-beta (Ab) amyloidosis and human AD brains. These aggregates, which bind to beta sheet-binding dyes, trigger Ab amyloidosis in microglia's endo-lys…